Publications

Recent Lab Publications

• Buchser WB, Pardinas JR, Shi Y, Bixby JL, Lemmon VP. 96-Well electroporation method for transfection of mammalian central neurons. Biotechniques. 2006 Nov; 41:619-224. Download PDF
  
  
• Tang N, He M, O'Riordan MA, Farkas C, Buck K, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases. J Neurochem. 2006 Mar;96(5):1480-90. Download PDF
  
  
• Liu J, Ball SL, Yang Y, Mei P, Zhang L, Shi H, Kaminski HJ, Lemmon VP, Hu H. A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1). Mech Dev. 2006 Feb 1 Download PDF
  
  
• Itoh K, Fushiki S, Kamiguchi H, Arnold B, Altevogt P, Lemmon V. Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions. Mol Cell Neurosci. 2005 Dec;30(4):624-9. Download PDF
  
  
• Cheng L, Lemmon S, Lemmon V. RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. J Neurochem. 2005 Aug;94(4):1102-10. Epub 2005 Jul 5. Download PDF
  
  
• Newpher TM, Smith RP, Lemmon V, Lemmon SK. In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. Dev Cell. 2005 Jul;9(1):87-98. Download PDF
  
  
• Itoh K, Shimono K, Lemmon V. Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus. Mol Cell Neurosci. 2005 Jun;29(2):245-9. Download PDF
  
  
• Cheng L, Itoh K, Lemmon V. L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region. J Neurosci. 2005 Jan 12;25(2):395-403. Download PDF
  
  
• Cheng L and Lemmon V. Pathological missense mutations of neural cell adhesion molecule L1 affect neurite outgrowth and branching on an L1 substrate. Mol Cell Neurosci. (2004) 27:522-530. Download Paper PDF    Download Supplementary Data PDF
  
  
• Itoh, K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, and Lemmon V. Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. (2004)165:145-154 Download PDF
  
  
• A.W. Schaefer, Y. Kamei, H. Kamiguchi, E.V. Wong, I. Rapoport, T. Kirchhausen, C.M. Beach, G. Landreth, S.K. Lemmon, V. Lemmon. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J. Cell Biology, 157: 1223–1232, 2002. Download PDF
  
  
• De Angelis, E., Brümmendorf, T., Cheng, L., Lemmon, V., and Kenwrick, S. Alternative Use of a Mini Exon of the L1 Gene Affects L1 Binding to Neural Ligands, J. Biol. Chem., 276 :32738-32742, 2001, J. Biol. Chem., 276 :32738-32742. Download PDF
  
  
• Long, K.E., Asou, H., Snider, M.D., Lemmon, V., The role of endocytosis in regulating L1 mediate adhesion. J. Biol. Chem., 276: 1285-1290, 2001 Download PDF
  
  
• Kamiguchi, H., Lemmon, V. Recycling of the Cell Adhesion Molecule L1 in Axonal Growth Cones. J. Neurosci., 15:3676-3686, 2000. Download PDF
  
  

Recent Review Articles

• Kooy RF, Verhoye MV, Lemmon V, Van Der Linden A. Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI). European Journal of Human Genetics. 2001; 9:153-159. Download PDF
  
  
• Brümmendorf, T., and Lemmon, V. IgCAMs: Cis-interactions and cytoplasmic adaptors regulate adhesion. Current Opinion in Cell Biology, 13:611-618, 2001 Download PDF
  
  
• Kamiguchi, H., and Lemmon, V. IgCAMs: Bi-directional signals underlying neurite growth. Current Opinion in Cell Biology, 12:598-605, 2000 Download PDF
  
  
• Long, K.E. and Lemmon, V. Dynamic regulation of cell adhesion molecules during axon outgrowth. J. Neurobiol. 44:230-245, 2000 Download PDF
  
  
• Kamiguchi, H., Hlavin, M.L., Yamasaki, M., Lemmon, V. Adhesion molecules and inherited diseases of the nervous system. Annual Reviews of Neuroscience, 1998, 21:97-125 Download PDF
  
  
• Kamiguchi, H., Hlavin, M.L., Lemmon, V. Role of L1 in neural development: what the knockouts tell us. Mol. Cell Neurosci. 12:48-55, 1998. Download PDF
  
  

Complete List of Publications
< 1977-1989 | 1990-1995 | 1996-1997 | 1998-1999 | 2000-2002 >

2000-2002

• Kamiguchi, H., Lemmon, V. Recycling of the Cell Adhesion Molecule L1 in Axonal Growth Cones J. Neurosci., 15:3676-3686, 2000. Download PDF
  
  
• Esch, T., Lemmon, V., Banker, G. Differential effects of NgCAM and N-cadherin on the development of axons and dendrites by cultured hippocampal neurons. J. Neurocytology 29:215-223, 2000 Download PDF
  
  
• Long, K.E. and Lemmon, V. Dynamic regulation of cell adhesion molecules during axon outgrowth. J. Neurobiol. 44:230-245, 2000. Download PDF
  
  
• Kamiguchi, H., and Lemmon, V. IgCAMs: Bi-directional signals underlying neurite growth. Current Opinion in Cell Biology, 12:598-605, 2000. Download PDF
  
  
• Kooy, R.F., Verhoye, M., Lemmon, V. and Van Der Linden, A., Analysis of mouse brain by magnetic resonance imaging (MRI), Eur J. Hum Genet. 9:153-159, 2001
  
  
• Brümmendorf, T., and Lemmon, V. IgCAMs: Cis-interactions and cytoplasmic adaptors regulate adhesion. Current Opinion in Cell Biology, 13:611-618, 2001. Download PDF
  
  
• Long, K.E., Asou, H., Snider, M.D., Lemmon, V., The role of endocytosis in regulating L1 mediate adhesion. J. Biol. Chem., 276: 1285-1290, 2001. Download PDF
  
  
• De Angelis, E., Brümmendorf, T., Cheng, L., Lemmon, V., and Kenwrick, S. Alternative Use of a Mini Exon of the L1 Gene Affects L1 Binding to Neural Ligands, J. Biol. Chem., 276 :32738-32742, 2001, J. Biol. Chem., 276 :32738-32742. Download PDF
  
  
• A.W. Schaefer, Y. Kamei, H. Kamiguchi, E.V. Wong, I. Rapoport, T. Kirchhausen, C.M. Beach, G. Landreth, S.K. Lemmon, V. Lemmon. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J. Cell Biology, 157: 1223–1232, 2002. Download PDF

1998-1999

• Kamiguchi, H., Hlavin, M.L., Yamasaki, M., Lemmon, V. Adhesion molecules and inherited diseases of the nervous system. Annual Reviews of Neuroscience, 1998, 21:97-125. Download PDF
  
  
• Fransen E, D'Hooge R, Van Camp G, Verhoye M, Sijbers J, Reyniers E, Soriano P, Kamiguchi H, Willemsen R, Koekkoek SKE, Zeeuw CI, Deyn PPD, Van der Linden A, Lemmon V, Kooy RF, Willems PJ. L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Human Molecular Genetics. 1998;7(6):999-1009. Download PDF



• Kamiguchi, H., Lemmon, V. A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone. J. Neurosci., 18:3749-3756, 1998
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• Kamiguchi, H., Long, K.E., Pendergast, M., Schaefer, A.W., Rapoport, I, Kirchhausen, T., Lemmon, V. The Neural Cell Adhesion Molecule L1 Interacts with the AP-2 Adaptor and Is Endocytosed via the Clathrin-Mediated Pathway. J. Neurosci. 1998 18:5311-5321 Download PDF
  
  
• Williams, S., Leventhal, C., Lemmon, V., Nedergaard, M., Goldman, S.A. Estrogen promotes the initial migration and inception of NgCAM-dependent calcium-signaling by new neurons of the adult songbird brain. Mol. Cell Neurosci. 13:41-55, 1999.
  
  
• Esch, T., Lemmon, V., Banker, G. Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons. J. Neurosci. 19:6417-6326, 1999 Download PDF
  
  
• Haney, C.A., Sahenk, Z., Li, C., Lemmon, V.P., Roder, J., Trapp, B.D. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. J. Cell Biol. 146:1173-1183, 1999 Download PDF
  
  
• Schaefer, A.W., Kamiguchi, H., Wong, E.V., Beach, C.M., Landreth, G., and Lemmon, V. Activation of the MAPK Signal Cascade by the Neural Cell Adhesion Molecule L1 Requires L1 Internalization. J. Biol. Chem. 274:37965-37973., 1999 Download PDF
  
  
• Nayeem, N., Steve Silletti, S., Xiu-Ming Yang, X.-M., Vance A. Lemmon, V.P., Reisfeld, R.A., Stallcup, W.B., Montgomery, A.M.P. A potential role for the plasmin(ogen) system in the posttranslational cleavage of the neural cell adhesion molecule L1'. J. Cell Science 112:4739-4749, 1999
  
  
• Schaefer, A.. and Lemmon, V. Signal transduction, neurite growth and IG superfamily adhesion molecules in the vertebrate nervous system. Ig superfamily molecules in the nervous system, Ed. P. Sonderegger, Harwood Academic Pub. 1998
  
  
• Kamiguchi, K., Schaefer, A.S., Long, K.E., Yamasaki, M., and Lemmon, V., The function of the cytoplasmic domain of the cell adhesion molecule L1 in normal and abnormal brain development. Frontiers of Neural Development, Keio Symposium, Vol 2, 241-248, 1999
  
  
• Kamiguchi, K., and Lemmon, V. Signal-mediated sorting of the cell adhesion molecule L1: role of its cytoplasmic domain. Frontiers of Neural Development, Keio Symposium, Vol 2, 255-260, 1999
  
  
• Yamasaki, M., and Lemmon, V., Mutations in L1CAM correlate with severity of developmental defects in brain development, Frontiers of Neural Development, Keio Symposium Vol 2, 273-275, 1999

1996-1997

• Goldman, S.A., Williams, S., Barami, K., Lemmon, V., Nedergaard, M. Transient coupling of Ng-CAM expression to Ng-CAM-dependent calcium-signalling during migration of new neurons in the adult songbird forebrain. Mol. and Cell Neurosci. 7: 29-45, 1996
  
  
• Wong, E.V., Schaefer, A.W., Landreth, G., Lemmon, V. Casein kinase II phosphorylates the neural cell adhesion molecule L1, J. Neurochem., 66:779-786, 1996
  
  
• Montgomery, A., Becker, J.C., Siu, C.-H., Lemmon, V.P., Cheresh, D.A., Pancock, J.D., Zhao, X., Reisfeld, R.A. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alphaVbeta3, J. Cell Biol. 132:475-485, 1996
  
  
• Burden-Gulley, S.M., Lemmon, V. L1/8D9, N-cadherin and laminin induce distinct distribution patterns of cytoskeletal elements in growth cones. Cell Motility and the Cytoskeleton 35:1-23, 1996
  
  
• Payne, H.R., Hemperly, J.J., Lemmon, V. N-cadherin expression and function in cultured oligodendrocytes. Dev. Br. Res. 97:9-15, 1996 Download PDF
  
  
• Wong, E.V., Schaefer, A.W., Landreth, G. and Lemmon, V. Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J. Biol. Chem. 271:18217-18233, 1996 Download PDF
  
  
• Drazba, J., Liljelund, P., Smith, C., Payne, R., Lemmon, V. Growth cone interactions with purified cell and substrate adhesion molecules visualized by interference reflection microscopy. Dev. Brain Res., 100:183-197, 1997 Download PDF
  
  
• Yamasaki M, Thompson P, Lemmon V. CRASH Syndrome: Mutations in L1CAM Correlate with Severity of the Disease. Neuropediatrics. 1997; 28:175-178. Download PDF



• Kamiguchi, H., Lemmon, V., The neural cell adhesion molecule L1: signaling pathways and growth cone motility. J. Neurosci. Res., 49:1-8, 1997 Download PDF
  
  
• Burden-Gulley, S.M., Pendergast, M. Lemmon, V., The role of the cell adhesion molecule L1 in axonal extension, growth cone motility and signal transduction, Cell and Tissue Res. 290:415-422, 1997

1990-1995

• Letourneau, P.C., Shattuck, T.A., Roche, F., Takeichi, M., and Lemmon, V., Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin. Dev. Bio. 138:430-442, 1990
  
  
• Drazba, J. and Lemmon, V., The role of cell adhesion molecules in neurite outgrowth on Muller cells. Dev. Bio. 138:82-93, 1990
  
  
• Snow, D.M., Lemmon, V., Carrino, D.A., Caplan, A.I., and Silver, J. Sulfated proteoglycans present in astroglial barriers during development in vivo inhibit neurite outgrowth in vitro. Exp. Neurol. 109:111-130, 1990
  
  
• Drazba, J., Pierce, M., and Lemmon, V. Studies of the developing chick retina using monoclonal antibody 8A2 that recognizes a novel set of gangliosides. Dev. Biol. 145: 154-163, 1991
  
  
• Hlavin, M.L. and Lemmon, V. Molecular structure and functional testing of human L1: an interspecies comparison. Genomics, 11, 416-423, 1991.
  
  
• Letourneau, P.C., Roche, F.K., Shattuck, T.A., Lemmon, V., and Takeichi, M. Interactions of Schwann cells with neurites and with other Schwann cells involve the calcium-dependent adhesion molecule, N-cadherin. J. Neurobiology, 22:707-720, 1991.
  
  
• Cervello, M., Lemmon, V., Landreth, G., and Rutishauser, U. Phosphorylation-dependent regulation of neurite fasciculation. Proc. Natl. Acad. Sci., USA, 88:10548-10552, 1991.
  
  
• Lemmon, V., Burden, S.M., Payne, H.R., Elmslie, G.J. and Hlavin, M.L. Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength. J. Neuroscience, 12:818-826, 1992
  
  
• Payne, H.R., Burden, S. and Lemmon, V. Modulation of growth cone morphology by substrate bound cell adhesion molecules. Cell Motility and the Cytoskeleton, 21:65-73, 1992.
  
  
• Sloan, S.F., Lemmon, V. and Koenig, E. Characterization of the retraction response of goldfish axons triggered by monoclonal antibody 8A2 in vitro. Cell Motility and the Cytoskeleton, 23:279-301, 1992.
  
  
• Sloan, S.F., Lemmon, V. and Koenig, E. Monoclonal antibody 8A2 induced retraction is mediated by protein phosphorylation in goldfish retinal ganglion cell axons. Dev. Biol., 156:230-242, 1993.
  
  
• Goldman, S.A., Lemmon, V., and Chin, S.S.-M. Migration of newly generated neurons upon ependymally-derived radial guide cells in explant cultures of the adult avian forebrain. Glia, 8:150-160, 1993.
  
  
• Payne, H.R., and Lemmon V. Glial cells of the O-2A lineage bind preferentially to N-cadherin and develop distinct morphologies. Dev. Biol. 159:595-607, 1993
  
  
• Barry, C.P., Xie, J., Lemmon, V., and Young, A.P. Molecular characterization of a multipromoter gene encoding a chicken filamin protein. J. Biological Chemistry 268:25577-25586, 1993
  
  
• Barami, K., Kirschenbaum, B., Lemmon, V., Goldman, S. N-cadherin and NgCAM/8D9 are involved serially in the migration of newly generated neurons into the adult song bird brain. Neuron, 13:567-582, 1994
  
  
• Ring, C., Lemmon, V., Halfter, W. Two chondroitin sulfate proteoglycans differentially expressed in the developing chick visual system. Dev. Biol. 168:11-27, 1995
  
  
• Burden-Gulley, S.M., Payne, H.R., Lemmon, V. Growth cones are actively influenced by substrate-bound adhesion molecules. J. Neurosci., 15:4370-4381, 1995
  
  
• Wong, E.V., Kenwrick, S, Willems, and V. Lemmon. Mutations in the cell adhesion molecule L1 cause mental retardation. Trends in Neuroscience. 18:168-172 Download PDF
  
  
• Brittis, P.A., Lemmon, V., Rutishauser, U., Silver, J. Cell adhesion molecules in concert with repulsive molecules govern intraretinal axon guidance: a time lapse study of the living retina. Mol and Cell Neurobiology, 6:433-449, 1995
  
  
• Fransen, E., Lemmon, V., Van Camp, G., Vits, L., Coucke, P., Willems, P.J. CRASH syndrome: a clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. European Journal of Human Genetics. 3:273-284, 1995
  
  
• Willbold, E., Reinicke, M., Lance-Jones, C., Lagenaur, C., Lemmon, V., Layer, P.G. Muller glia stabilizes cell columns during retinal development: lateral cell migration but not neuropil growth is inhibited in mixed chick-quail retinospheroids. Eur. J. Neurosci. 7:2277-2284, 1995
  
  
• Wong EV, Cheng G, Payne HR, Lemmon V. The cytoplasmic domain of the cell adhesion molecule L1 is not required for homophilic adhesion. Neuroscience Letters. 1995; 200:155-158. Download PDF
  
  



• Lemmon, V. "How to Talk to Children" in : How-To Book; a primer on working with schools, Soc. for Neuroscience, Committee on Neuroscience Literacy, 1992-1995, editor 1994 and 1995
  
  
• Seminars in Developmental Biology: 6:2 Cell Interaction Molecules in Development, Guest Editors: U. Rutishauser and V. Lemmon 1995

1977-1989

• Anderson, K.V., Lemmon, V., and Rosing, H.S. Response properties of cells in the dorsal lateral geniculate nucleus of the albino rat. J. Neurosci. Res. 3:143-152, 1977. Download PDF
  
  
• Lemmon, V. and Anderson, K.V. Behavioral correlates of constant light-induced retinal degeneration. Exp. Neurol. 63:34-49, 1979. Download PDF
  
  
• Lemmon, V. and Anderson, K.V. Central neurophysiologic correlates of constant light-induced retinal degeneration. Exp. Neurol. 63:50-75, 1979. Download PDF
  
  
• Anderson, K.V. and Lemmon, V. The effects of constant light on visually guided behavior. In: The Effects of Constant Light on Visual Processes. T.P. Williams and B.N. Baker (Eds.), Plenum Press, 1980.
  
  
• Anderson, K.V., Lemmon, V., and O'Steen, W.K. Neurophysiological properties of visual neurons in rats with light damaged retina. In: The Effects of Constant Light on Visual Processes. T.P. Williams and B.N. Baker (Eds.), Plenum Press, 1980.
  
  
• Lemmon, V. and Gottlieb, D.I. Techniques for the production of monoclonal antibodies against the chick retina. In: Syllabus of the 1981 short course of the Society for Neuroscience: New Approaches in Developmental Neurobiology.
  
  
• Lemmon, V. and Pearlman, A.L. Does laminar position determine the receptive field properties of cortical neurons: A study of corticotectal cells in area 17 of the normal mouse and reeler mouse. J. Neurosci. 1:83-93, 1981.
  
  
• Lemmon, V., Staros, E.B., Perry, H.E., and Gottlieb, D.I. A monoclonal antibody which binds to the surface of chick brain cells and myotubes: Cell selectivity and properties of the antigen. Dev. Brain Res. 255:349-360, 1982.
  
  
• Lemmon, V. and Gottlieb, D.I. Monoclonal antibodies selective for the inner portion of the chick retina. J. Neurosci. 2:531-535, 1982.
  
  
• Simmons, P.A., Lemmon, V., and Pearlman, A.L. Afferent and efferent connections of the striate and extrastriate visual cortex of the normal and reeler mouse. .J. Comp. Neurol. 211:295-308, 1982.
  
  
• Lemmon, V. and Rieser, G. The development distribution of vimentin in the chick retina. Dev. Brain Res. 11:191-198, 1983.
  
  
• Lemmon, V. Monoclonal antibodies specific for glia in the chick central nervous system. Dev. Brain Res. 23:111-120, 1985.
  
  
• Lemmon, V. The localization of a filamin-like protein in glia of the chick central nervous system. J. Neurosci. 6:43-51, 1986.
  
  
• Lemmon, V. A monoclonal antibody that binds to cones. Invest. Ophthalmol. and Vis. Sci. 27:831-836, 1986.
  
  
• Lemmon, V. and McLoon, S. The appearance of an L1 like molecule in the chick primary visual pathway. J. Neurosci. 6:2987-2994, 1986.
  
  
• Hyndman, A.G. and Lemmon, V. Neurons and glia in purified retinal cultures identified by monoclonal antibodies to intermediate filaments. Neurosci. Lett. 75:121-126, 1987.
  
  
• Lagenaur, C. and Lemmon, V. A L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc. Natl. Acad. Sci., USA 84:7753-7757, 1987.
  
  
• Lemmon, S.K., Lemmon, V.P., and Jones, E.W. Characterization of yeast clathrin and anti-clathrin heavy chain monoclonal antibodies. J. Cellular Biochem. 36: 329-340, 1988.
  
  
• Lemmon, V., Farr, K. and Lagenaur, C. The role of a cell adhesion molecule in neurite outgrowth and regeneration. In: Cell Interactions in Visual Development. S.R. Hilger and J.B. Sheffield (Eds.), Springer Verlag, 1988.
  
  
• Lemmon, V. A monoclonal antibody that binds to the surface of photoreceptors. Dev. Brain Res. 39:117-123, 1988.
  
  
• Risau, W. and Lemmon, V. Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev. Bio. 125:441-450, 1988.
  
  
• Lemmon, V., Farr, K., Lagenaur, C. L1 mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron, 2:1597-1603, 1989.

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